Controlled Release

Authored by: Brent Vernon , Michael Wegner

Encyclopedia of Biomaterials and Biomedical Engineering, Second Edition

Print publication date:  May  2008
Online publication date:  May  2008

Print ISBN: 9781420078022
eBook ISBN: 9781498761437
Adobe ISBN:

10.1081/E-EBBE2-120007275

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Abstract

Delivery of compounds to a specific location (spatial control) or with a specific pattern (temporal control), or both, is called controlled release. Controlled release system types are classified as mechanical/electrical systems, polymeric systems, and biological systems. Examples and history of these different types of controlled-release systems are presented in this entry. In these systems, modeling and analysis of the release profile is required because the rate of release is crucial. Furthermore, controlled-release technology often combines drug and device and sometimes biologics into one product. This combination of drug and device results in regulatory issues unique to these systems.

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