Angiogenesis Inhibitors

Authored by: Shaker A. Mousa , Ahmed S. Mousa

Encyclopedia of Biomaterials and Biomedical Engineering, Second Edition

Print publication date:  May  2008
Online publication date:  May  2008

Print ISBN: 9781420078022
eBook ISBN: 9781498761437
Adobe ISBN:


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The field of angiogenesis modulation is at a major crossroads. A tremendous advancement in basic science in this field is providing excellent support, though there is a lack of strong clinical support at this point with the exception of the recent data on anti-vascular endothelial growth factor (VEGF) as an adjunct to chemotherapy in solid tumor. Clinical outcome should include benefit/risk ratio, cost effectiveness, and hard end points including mortality, quality of life as opposed to tumor size reduction or decrease, and microvascular density with anti-angiogenesis agents.

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