Bone Remodeling

Authored by: Elisabeth H. Burger , Jenneke Klein‐Nulend , Theo H. Smit

Encyclopedia of Biomaterials and Biomedical Engineering, Second Edition

Print publication date:  May  2008
Online publication date:  May  2008

Print ISBN: 9781420078022
eBook ISBN: 9781498761437
Adobe ISBN:


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This entry explains the details of bone remodelling, including the separate activities of osteoclasts and osteoblasts, and discusses recent findings that explain how remodeling leads to mechanically adapted bone tissue, and the role of the mature bone cells or osteocytes in this process. A hypothesis is presented that relates osteocyte apoptosis resulting from disuse, to the loading-aligned tunnelling activity of osteoclasts. Last, the entry discusses how adaptive remodeling leads to unwanted bone loss, e.g., around arthroplastic implants and after tooth extraction.

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