Animal Models for Bone Tissue Engineering

Authored by: Mark P. Mooney , Michael I. Siegel

Encyclopedia of Biomaterials and Biomedical Engineering, Second Edition

Print publication date:  May  2008
Online publication date:  May  2008

Print ISBN: 9781420078022
eBook ISBN: 9781498761437
Adobe ISBN:

10.1081/E-EBBE2-120041698

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Abstract

This entry presents a number of practical criteria to facilitate the animal model choice for bone tissue engineering studies; reviews the advantages and disadvantages of various animal models for basic bone biology and the testing of bone replacement materials (BRMs) in critical-sized defects (CSDs); and identifies animal models with clinically relevant pathologies that may be used to develop specific bone tissue engineering paradigms and strategies. This discussion is intended as an aid to less experienced researchers and students designing experimental studies, and to tissue engineers and clinicians who must critically evaluate the results obtained from published animal studies for validity and potential extrapolation to the human clinical condition.

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