Animal Surrogate Systems for Toxicity Testing

Authored by: Michael L. Shuler , Gretchen J. McAuliffe , Daniel A. Tatosian

Encyclopedia of Biomaterials and Biomedical Engineering, Second Edition

Print publication date:  May  2008
Online publication date:  May  2008

Print ISBN: 9781420078022
eBook ISBN: 9781498761437
Adobe ISBN:

10.1081/E-EBBE2-120041849

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Abstract

This entry gives a brief overview of many of the animal surrogate systems used for toxicity testing, including mathematical models, single cell type models, barrier models, cocultures, three-dimensional models, and multicell type devices. It demonstrates how toxicity can be predicted prior to animal or human studies.

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