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Handbook of Biomarkers and Precision Medicine

Edited by: Claudio Carini , Mark Fidock , Alain van Gool

Print publication date:  May  2019
Online publication date:  April  2019

Print ISBN: 9781498762588
eBook ISBN: 9780429202872
Adobe ISBN:

 Cite  Marc Record

Book description

"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health

Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development.


  • Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies
  • Lessons-learned from successful Precision Medicine case studies
  • A variety of exciting and emerging biomarker technologies
  • The next frontiers and future challenges of biomarkers in Precision Medicine

Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings?s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

Table of contents

Prelims Download PDF
Chapter  1:  Definitions and Conceptual Framework of Biomarkers in Precision Medicine Download PDF
Chapter  2:  In Search of Predictive Biomarkers in Cancer Immunotherapy Download PDF
Chapter  3:  Integrating Personalized Medicine in the Health Care Download PDF
Chapter  4:  Regulatory Strategies to Accelerate the Implementation of Biomarkers and Companion Diagnostics Download PDF
Chapter  5:  Lost in Translation Download PDF
Chapter  6:  Application of Pharmacokinetic and Pharmacodynamic Modeling of Biomarkers of Efficacy in Translational Research Download PDF
Chapter  7:  The DIAMONDS Platform Download PDF
Chapter  8:  Predicting the Safety of Drug Targets Download PDF
Chapter  9:  Unwanted Immunogenicity Responses to Biotherapeutics Download PDF
Chapter  10:  Biomarker Use for Advanced Screening of Drug-Induced Kidney Injury Download PDF
Chapter  11:  Soluble Biomarkers for Drug-Induced Cardiotoxicity Download PDF
Chapter  12:  Lost in Translation Download PDF
Chapter  13:  Necessary Characterization of Biomarkers to Be “Fit for Purpose” Download PDF
Chapter  14:  Crucial Role of High Quality Biosamples in Biomarker Development Download PDF
Chapter  15:  Informatics Solutions for Biomarker Discovery and Personalized Medicine in Clinical Care Download PDF
Chapter  16:  Systems Biology Approaches to Identify New Biomarkers Download PDF
Chapter  17:  The Need for Global Collaboration in Translational Medicine Download PDF
Chapter  18:  Overview of Biomarker Discovery and Statistical Considerations Download PDF
Chapter  19:  Overview of Classical Design in Biomarker-Informed Clinical Trials Download PDF
Chapter  20:  Novel Biomarker Guided Clinical Trial Designs Download PDF
Chapter  21:  Outsourcing Biomarkers in Clinical Trials Download PDF
Chapter  22:  Case Studies for Biomarker-Based Clinical Trials Download PDF
Chapter  23:  Informational Designs and Potential Applications to Rare Disease Download PDF
Chapter  24:  Paving a New Era in Patient Centric Care through Innovations in Precision Medicine Download PDF
Chapter  25:  Integrating Molecular Testing into Early Stage Clinical Applications Download PDF
Chapter  26:  Ectopic Gene Deregulations and Chromosome Conformations Download PDF
Chapter  27:  Challenges and Opportunities of Next Generation Sequencing Companion Diagnostics Download PDF
Chapter  28:  Implementing Companion Diagnostics Download PDF
Chapter  29:  Publishing Biomedical Research Findings Download PDF
Chapter  30:  Computational Biology Download PDF
Chapter  31:  Expectations for Quality Control Download PDF
Chapter  32:  Development of Maraviroc and the Companion Diagnostic HIV Tropism Assay Download PDF
Chapter  33:  Case Studies Download PDF
Chapter  34:  Factor Xa Download PDF
Chapter  35:  Delivering Companion Diagnostics for Complex Biomarkers Download PDF
Chapter  36:  Delivering the Personalized Medicine Promise Download PDF
Chapter  37:  Development, Launch, and Adoption of a Pharmacodiagnostic Download PDF
Chapter  38:  Biomarker Consortia to Drive BM Discovery and Clinical Applications in the UK Download PDF
Chapter  39:  Measuring the Success of U.S. Biomarker Consortia Download PDF
Chapter  40:  The Value of Public–Private Partnerships in the Netherlands Download PDF
Chapter  41:  A New Era of Personalized Medicine Download PDF
Chapter  42:  The Impact of Epigenetics on the Future of Personalized Medicine Download PDF
Chapter  43:  Incorporating Predictive Imaging Biomarkers in Clinical Trials for Personalised Healthcare Download PDF
Chapter  44:  Innovation in Metabonomics to Improve Personalized Health Care Download PDF
Chapter  45:  Predictive Cancer Biomarkers Download PDF
Chapter  46:  Glycomics as an Innovative Approach for Personalized Medicine Download PDF
Chapter  47:  miRNAs as Novel Biomarkers for Health and Disease Download PDF
Chapter  48:  Targeted Proteomics for Absolute Quantification of Protein Biomarkers in Serum and Tissues Download PDF
Chapter  49:  Integrated Omics for Tissue-Based Mapping of the Human Proteome Download PDF
Chapter  50:  Proteogenomics and Multi-omics Data Integration for Personalized Medicine Download PDF
Chapter  51:  Sequencing Approaches for Personalized Cancer Therapy Selection in Pathology Download PDF
Chapter  52:  Mass Spectrometry Imaging Download PDF
Chapter  53:  Insights of Personalized Medicine from the Gut Microbiome Download PDF
Chapter  54:  Precision Mucosal Sampling and Biomarkers in Allergic Rhinitis and Asthma Download PDF
Chapter  55:  Stratified Medicine in Autoimmune Diseases Download PDF
Chapter  56:  Biomarkers of Systemic Lupus Erythematosus Download PDF
Chapter  57:  Advances in Cardiovascular Diagnostics Download PDF
Chapter  58:  Biomarkers for Psychiatric Disease Download PDF
Chapter  59:  Progressing Towards Precision Psychiatry Download PDF
Chapter  60:  Identification of Biomarkers for the Diagnosis, Prediction, and Progression of Alzheimer’s Disease Download PDF
Chapter  61:  Biomarkers in Lung Cancer Download PDF
Chapter  62:  Translational Science in Modern Pharmaceutical R&D Download PDF
Chapter  63:  Biomarker Qualification and Companion Diagnostics Download PDF
Chapter  64:  Not All Biomarkers Are Worthwhile Download PDF
Chapter  65:  Research Reproducibility Download PDF
Chapter  66:  Can Big Data Analytics Recapitulate Biology? A Survey of Multi-omics Data Integration Approaches Download PDF
Chapter  67:  Can Health Care Be Made More Affordable by the Use of Biomarkers? Download PDF
Chapter  68:  Omics Driven Medicine for Democratizing Health Care Delivery and Health Economics Download PDF
Index Download PDF
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