ABSTRACT

Organophosphorus compounds (OPs) are widely used in a range of agricultural, industrial and domestic applications. There is concern over their ability to induce acute and delayed neurotoxicity in non-target organisms including humans, by inhibition of acetylcholinesterase or disruption of other cellular activities in a variety of ways, respectively. This chapter discusses the potential importance of mitochondrial disruption as a key event in OP-induced neurotoxicity.