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Handbook of Nuclear Medicine and Molecular Imaging for Physicists

Radiopharmaceuticals and Clinical Applications, Volume III

Edited by: Michael Ljungberg

Print publication date:  April  2022
Online publication date:  March  2022

Print ISBN: 9781138593312
eBook ISBN: 9780429489501
Adobe ISBN:

10.1201/9780429489501
 Cite  Marc Record

Book description

This state-of-the-art handbook, the third and final in a series that provides medical physicists with a comprehensive overview into the field of nuclear medicine, focuses on highlighting the production and application of radiopharmaceuticals. With this, the book also describes the chemical composition of these compounds, as well as some of the main clinical applications where radiopharmaceuticals may be used.



Following an introduction to the field of radiopharmacy, three chapters in this book are dedicated towards in-depth descriptions of common radionuclides and radiopharmaceuticals used during diagnostic studies utilizing planar/Single Photon Emission Computed Tomography (SPECT) imaging, in addition to during Positron Emission Tomography (PET) imaging, and, finally, radiotherapy. These chapters are followed by those describing procedures relating to quality control and manufacturing (good manufacturing practices) also encompassing aspects such as environmental compliance. Furthermore, this volume illustrates how facilities handling these chemicals should be designed to comply with set regulations.



Like many pharmaceuticals, the development of radiopharmaceuticals relies heavily on the use of mouse models. Thus, the translation of radiopharmaceuticals (i.e., the process undertaken to assure that the functionality and safety of a newly developed drug is maintained also in a human context), is covered in a later chapter. This is followed by a chapter emphasising the importance of safe waste disposal and how to assure that these procedures meet the requirements set for the disposal of hazardous waste.



Several chapters have also been dedicated towards describing various medical procedures utilizing clinical nuclear medicine as a tool for diagnostics and therapeutics. As physicists may be involved in clinical trials, a chapter describing the procedures and regulations associated with these types of studies is included. This is followed by a chapter focusing on patient safety and another on an imaging modality not based on ionizing radiation – ultrasound. Finally, the last chapter of this book discusses future perspectives of the field of nuclear medicine.



This text will be an invaluable resource for libraries, institutions, and clinical and academic medical physicists searching for a complete account of what defines nuclear medicine.







  • The most comprehensive reference available providing a state-of-the-art overview of the field of nuclear medicine






  • Edited by a leader in the field, with contributions from a team of experienced medical physicists, chemists, engineers, scientists, and clinical medical personnel






  • Includes the latest practical research in the field, in addition to explaining fundamental theory and the field's history


Table of contents

Prelims Download PDF
Chapter  1:  Principles behind Radiopharmacy Download PDF
Chapter  2:  Radiopharmaceuticals for Diagnostics Download PDF
Chapter  3:  Radiopharmaceuticals for Diagnostics Download PDF
Chapter  4:  Radiopharmaceuticals for Radionuclide Therapy Download PDF
Chapter  5:  Design Considerations for a Radiopharmaceutical Production Facility Download PDF
Chapter  6:  Methods and Equipment for Quality Control of Radiopharmaceuticals Download PDF
Chapter  7:  Environmental Compliance and Control for Radiopharmaceutical Production Download PDF
Chapter  8:  GMP Download PDF
Chapter  9:  Management of Radioactive Waste in Nuclear Medicine Download PDF
Chapter  10:  Translation of Radiopharmaceuticals Download PDF
Chapter  11:  Radionuclide Bone Scintigraphy Download PDF
Chapter  12:  Radionuclide Examination of the Kidneys Download PDF
Chapter  13:  Neuroimaging in Nuclear Medicine Download PDF
Chapter  14:  Methodology and Clinical Implementation of Ventilation/Perfusion Tomography for Diagnosis and Follow-up of Pulmonary Embolism and Other Pulmonary Diseases Download PDF
Chapter  15:  Myocardial Perfusion Imaging Download PDF
Chapter  16:  Infection and Inflammation Download PDF
Chapter  17:  Special Considerations in Pediatric Nuclear Medicine Download PDF
Chapter  18:  Antibody-based Radionuclide Imaging Download PDF
Chapter  19:  Radionuclide-based Diagnosis and Therapy of Prostate Cancer Download PDF
Chapter  20:  Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumours Download PDF
Chapter  21:  Lymphoscintigraphy Download PDF
Chapter  22:  Diagnostic Ultrasound Download PDF
Chapter  23:  Clinical Trials Download PDF
Chapter  24:  Introduction to Patient Safety and Improvement Knowledge Download PDF
Chapter  25:  Closing Remarks Download PDF
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