Abstract

PET and SPECT imaging are methodologies used in a variety of preclinical research applications. Both imaging modalities have shown to be important in the development of new radiopharmaceuticals for clinical and research applications. In biological research preclinical PET and SPECT imaging can provide a better understanding of molecular pathways of disease and therapy. Using human disease models in mice and rodents, preclinical imaging can be used to facilitate the discovery and design of new diagnostic and therapeutic agents. Both modalities are well-established imaging technologies and integrated laboratory tools that are used to make important contributions to a wide variety of fields in medical and biological sciences.