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Handbook of Tissue Optical Clearing

New Prospects in Optical Imaging

Edited by: Valery V. Tuchin , Dan Zhu , Elina A. Genina

Print publication date:  February  2022
Online publication date:  February  2022

Print ISBN: 9780367895099
eBook ISBN: 9781003025252
Adobe ISBN:

10.1201/9781003025252
 Cite  Marc Record

Book description

Biomedical photonics is currently one of the fastest growing fields, connecting research in physics, optics, and electrical engineering coupled with medical and biological applications. It allows for the structural and functional analysis of tissues and cells with resolution and contrast unattainable by any other methods.

However, the major challenges of many biophotonics techniques are associated with the need to enhance imaging resolution even further to the sub-cellular level as well as translate them for in vivo studies. The tissue optical clearing method uses immersion of tissues into optical clearing agents (OCAs) that reduces the scattering of tissue and makes tissue more transparent and this method has been successfully used ever since.

This book is a self-contained introduction to tissue optical clearing, including the basic principles and in vitro biological applications, from in vitro to in vivo tissue optical clearing methods, and combination of tissue optical clearing and various optical imaging for diagnosis. The chapters cover a wide range of issues related to the field of tissue optical clearing: mechanisms of tissue optical clearing in vitro and in vivo; traditional and innovative optical clearing agents; recent achievements in optical clearing of different tissues (including pathological tissues) and blood for optical imaging diagnosis and therapy.

This book provides a comprehensive account of the latest research and possibilities of utilising optical clearing as an instrument for improving the diagnostic effectiveness of modern optical diagnostic methods.

The book is addressed to biophysicist researchers,?graduate students?and postdocs?of biomedical specialties, as well as biomedical engineers and physicians interested in the development and application of optical methods in medicine.

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Key features:

  • The first collective reference to collate all known knowledge on this topic
  • Edited by experts in the field with chapter contributions from subject area specialists
  • Brings together the two main approaches in immersion optical clearing into one cohesive book

Table of contents

Prelims Download PDF
Chapter  1:  Tissue optical clearing mechanisms Download PDF
Chapter  2:  Tissue optical clearing for Mueller matrix microscopy Download PDF
Chapter  3:  Traditional and innovative optical clearing agents Download PDF
Chapter  4:  Chemical enhancers for improving tissue optical clearing efficacy Download PDF
Chapter  5:  Human skin autofluorescence and optical clearing Download PDF
Chapter  6:  Molecular modeling of post-diffusion phase of optical clearing of biological tissues Download PDF
Chapter  7:  Refractive index measurements of tissue and blood components and OCAs in a wide spectral range Download PDF
Chapter  8:  Water migration at skin optical clearing Download PDF
Chapter  9:  Optical and mechanical properties of cartilage during optical clearing Download PDF
Chapter  10:  Compression optical clearing Download PDF
Chapter  11:  Optical clearing for multiscale tissues and the quantitative evaluation of clearing methods in mouse organs Download PDF
Chapter  12:  Ultrafast aqueous clearing methods for 3D imaging Download PDF
Chapter  13:  Challenges and opportunities in hydrophilic tissue clearing methods Download PDF
Chapter  14:  Combination of tissue optical clearing and 3D fluorescence microscopy for high-throughput imaging of entire organs and organisms  Download PDF
Chapter  15:  Endogenous fluorescence preservation from solvent-based optical clearing Download PDF
Chapter  16:  Progress in ex situ tissue optical clearing – shifting immuno-oncology to the third dimension Download PDF
Chapter  17:  In vivo skin optical clearing methods for blood flow and cell imaging Download PDF
Chapter  18:  In vivo skull optical clearing for imaging cortical neuron and vascular structure and function Download PDF
Chapter  19:  In vivo skin optical clearing in humans Download PDF
Chapter  20:  Optical clearing of blood and tissues using blood components Download PDF
Chapter  21:  Blood and lymph flow imaging at optical clearing Download PDF
Chapter  22:  Optical clearing aided photoacoustic imaging in vivo  Download PDF
Chapter  23:  Enhancement of contrast in photoacoustic – fluorescence tomography and cytometry using optical clearing and contrast agents Download PDF
Chapter  24:  Tissue optical clearing in the terahertz range Download PDF
Chapter  25:  Magnetic resonance imaging study of diamagnetic and paramagnetic agents for optical clearing of tumor-specific fluorescent signal in vivo  Download PDF
Chapter  26:  Use of optical clearing and index matching agents to enhance the imaging of caries, lesions, and internal structures in teeth using optical coherence tomography and SWIR imaging Download PDF
Chapter  27:  Optical clearing of adipose tissue Download PDF
Chapter  28:  Diabetes mellitus-induced alterations of tissue optical properties, optical clearing efficiency, and molecular diffusivity Download PDF
Chapter  29:  Tissue optical clearing for in vivo detection and imaging diabetes induced changes in cells, vascular structure, and function Download PDF
Chapter  30:  Light operation on cortex through optical clearing skull window Download PDF
Chapter  31:  The role of optical clearing to enhance the applications of in vivo OCT and photodynamic therapy: Towards PDT of pigmented melanomas and beyond Download PDF
Chapter  32:  Combination of tissue optical clearing and OCT for tumor diagnosis via permeability coefficient measurements Download PDF
Chapter  33:  Optical clearing for cancer diagnostics and monitoring Download PDF
Chapter  34:  Contrast enhancement and tissue differentiation in optical coherence tomography with mechanical compression Download PDF
Chapter  35:  Measurement of the dermal beta-carotene in the context of multimodal optical clearing Download PDF
Chapter  36:  Optical clearing and molecular diffusivity of hard and soft oral tissues Download PDF
Chapter  37:  Optical clearing and Raman spectroscopy: In vivo applications Download PDF
Index Download PDF
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