ABC in Nuclear Imaging

Authored by: Y. Fan , Steven R. Meikle , Georgios I. Angelis , Arkadiusz Sitek

Handbook of Approximate Bayesian Computation

Print publication date:  August  2018
Online publication date:  August  2018

Print ISBN: 9781439881507
eBook ISBN: 9781315117195
Adobe ISBN:

10.1201/9781315117195-21

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Abstract

Nuclear imaging technologies produce non-invasive measures of a broad range of physiological functions, using externally detected electromagnetic radiation originating from radiopharmaceuticals administered to the subject. The main nuclear imaging modalities PET (positron emission tomography) and SPECT (single photon emission computed tomography) are the backbones of the field of molecular imaging, where they are used extensively in both clinical settings and pre-clinical research with animals to study disease mechanisms and test effectiveness of new therapies. Typical applications include glucose metabolism studies for cancer detection and evaluation and cardiac imaging, imaging of blood flow and volume, and it is one of the few methods available to neuroscientists to non-invasively study biochemical processes within the living brain, such as receptor binding, drug occupancy, or neurotransmitter release.

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