ABSTRACT

Handbook of Statistical Methods for Case-Control Studies is written by leading researchers in the field. It provides an in-depth treatment of up-to-date and currently developing statistical methods for the design and analysis of case-control studies, as well as a review of classical principles and methods. The handbook is designed to serve as a reference text for biostatisticians and quantitatively-oriented epidemiologists who are working on the design and analysis of case-control studies or on related statistical methods research. Though not specifically intended as a textbook, it may also be used as a backup reference text for graduate level courses.

Book Sections

  • Classical designs and causal inference, measurement error, power, and small-sample inference
  • Designs that use full-cohort information
  • Time-to-event data
  • Genetic epidemiology

About the Editors

Ørnulf Borgan is Professor of Statistics, University of Oslo. His book with Andersen, Gill and Keiding on counting processes in survival analysis is a world classic.

Norman E. Breslow was, at the time of his death, Professor Emeritus in Biostatistics, University of Washington. For decades, his book with Nick Day has been the authoritative text on case-control methodology.

Nilanjan Chatterjee is Bloomberg Distinguished Professor, Johns Hopkins University. He leads a broad research program in statistical methods for modern large scale biomedical studies.

Mitchell H. Gail is a Senior Investigator at the National Cancer Institute. His research includes modeling absolute risk of disease, intervention trials, and statistical methods for epidemiology.

Alastair Scott was, at the time of his death, Professor Emeritus of Statistics, University of Auckland. He was a major contributor to using survey sampling methods for analyzing case-control data.

Chris J. Wild is Professor of Statistics, University of Auckland. His research includes nonlinear regression and methods for fitting models to response-selective data.

part I|37 pages

Introduction

chapter 1|12 pages

Origins of the Case-Control Study

ByNorman E. Breslow, Noel Weiss

chapter 2|23 pages

Design Issues in Case-Control Studies

ByDuncan C. Thomas

part II|166 pages

Classical Case-Control Studies

chapter 3|22 pages

Basic Concepts and Analysis

ByBarbara McKnight

chapter 4|14 pages

Matched Case-Control Studies

ByBarbara McKnight

chapter 5|10 pages

Multiple Case or Control Groups

ByBarbara McKnight

chapter 6|29 pages

Causal Inference from Case-Control Studies

ByVanessa Didelez, Robin J. Evans

chapter 7|15 pages

The Case-Crossover Study Design in Epidemiology

ByJoseph A. “Chris” Delaney, Samy Suissa

chapter 8|30 pages

Small Sample Methods

ByJinko Graham, Brad McNeneys, Robert Platt

chapter 9|26 pages

Power and Sample Size for Case-Control Studies

ByMitchell H. Gail, Sebastien Haneuse

chapter 10|16 pages

Measurement Error and Case-Control Studies

ByNorman E. Breslow, Noel Weiss

part III|77 pages

Case-control Studies that Use Full-Cohort Information

chapter 11|11 pages

Alternative Formulation of Models in Case-Control Studies

ByNorman E. Breslow, Noel Weiss

chapter 12|20 pages

Multi-Phase Sampling

ByNorman E. Breslow, Noel Weiss

chapter 13|11 pages

Calibration in Case-Control Studies

ByNorman E. Breslow, Noel Weiss

chapter 14|10 pages

Secondary Analysis of Case-Control Data

ByNorman E. Breslow, Noel Weiss

chapter 15|21 pages

Response Selective Study Designs Using Existing Longitudinal Cohorts

ByNorman E. Breslow, Noel Weiss

part IV|139 pages

Case-Control Studies for Time-to-Event Data

chapter 16|17 pages

Cohort Sampling for Time-to-Event Data: An Overview

ByNorman E. Breslow, Noel Weiss

chapter 17|25 pages

Survival Analysis of Case-Control Data: A Sample Survey Approach

ByNorman E. Breslow, Noel Weiss

chapter 18|21 pages

Nested Case-Control Studies: A Counting Process Approach

ByNorman E. Breslow, Noel Weiss

chapter 19|21 pages

Inverse Probability Weighting in Nested Case-Control Studies

ByNorman E. Breslow, Noel Weiss

chapter 20|18 pages

Multiple Imputation for Sampled Cohort Data

ByNorman E. Breslow, Noel Weiss

chapter 21|14 pages

Maximum Likelihood Estimation for Case-Cohort and Nested Case-Control Studies

ByDonglin Zeng, Dan-Yu Lin

chapter 22|17 pages

The Self-Controlled Case Series Method

ByPaddy Farrington, Heather Whitaker

part V|106 pages

Case-Control Studies in Genetic Epidemiology

chapter 24|21 pages

Analysis of Gene-Environment Interactions

ByNorman E. Breslow, Noel Weiss

chapter 25|16 pages

Two-Stage Testing for Genome-Wide Gene-Environment Interactions

ByJames Y. Dai, Li Hsu, Charles Kooperberg

chapter 26|20 pages

Family-Based Case-Control Approaches to Study the Role of Genetics

ByClarice R. Weinberg, Min Shi, David M. Umbach

chapter 27|20 pages

Mixed Models for Case-Control Genome-Wide Association Studies: Major Challenges and Partial Solutions

ByDavid Golan, Saharon Rosset, Dan-Yu Lin

chapter 28|14 pages

Analysis of Secondary Phenotype Data under Case-Control Designs

ByGuoqing Diao, Donglin Zeng, Dan-Yu Lin