Family-Based Case-Control Approaches to Study the Role of Genetics

Authored by: Clarice R. Weinberg , Min Shi , David M. Umbach

Handbook of Statistical Methods for Case-Control Studies

Print publication date:  July  2018
Online publication date:  June  2018

Print ISBN: 9781498768580
eBook ISBN: 9781315154084
Adobe ISBN:


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Family-based study designs offer a useful alternative to population-based designs, particularly for studies of genetic contributions to conditions that develop early in life, such as birth defects, childhood cancers, or psychiatric disorders. This chapter will provide an introduction to methods based on genetic studies of nuclear families where at least one offspring has developed the condition of interest.

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