ABSTRACT
Case-control studies have been used in genetics from its early days. The intuitive idea that when a condition is rare, it is worthwhile to make an effort to collect a large sample of cases was obvious to the fathers of the field even before concepts such as statistical power were introduced. It is therefore no wonder that as the technical capability to genotype genetic markers emerged, it was often applied in the context of a case-control study of a disease such as diabetes, schizophrenia or hypertension.
