Mixed Models for Case-Control Genome-Wide Association Studies: Major Challenges and Partial Solutions

Authored by: David Golan , Saharon Rosset , Dan-Yu Lin

Handbook of Statistical Methods for Case-Control Studies

Print publication date:  July  2018
Online publication date:  June  2018

Print ISBN: 9781498768580
eBook ISBN: 9781315154084
Adobe ISBN:

10.1201/9781315154084-27

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Abstract

Case-control studies have been used in genetics from its early days. The intuitive idea that when a condition is rare, it is worthwhile to make an effort to collect a large sample of cases was obvious to the fathers of the field even before concepts such as statistical power were introduced. It is therefore no wonder that as the technical capability to genotype genetic markers emerged, it was often applied in the context of a case-control study of a disease such as diabetes, schizophrenia or hypertension.

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