Fiber-Based OCT: From Optical Design to Clinical Applications

Authored by: V. Gelikonov , G. Gelikonov , M. Kirillin , N. Shakhova , A. Sergeev , N. Gladkova , E. Zagaynova

Handbook of Photonics for Biomedical Science

Print publication date:  May  2010
Online publication date:  May  2010

Print ISBN: 9781439806289
eBook ISBN: 9781439806296
Adobe ISBN:


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This chapter is devoted to the application of a fiber-based OCT device for clinical diagnosis of pathologies. The device design and its customizing by developing optical probes for particular endoscopic applications are discussed. The device and various probes are presented schematically. Examples of using the developed customized OCT modalities in clinical in vivo studies are given. The device is shown to be effective for diagnosis of cervical, bladder, and gastrointestinal cancer. In combination with fluorescent cystoscopy OCT is an almost perfect technique for endoscopic diagnosis of early bladder cancer. Because of its high sensitivity to cancer, OCT can also be used for presurgery planning and surgery guidance of the tumor borders.

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