In Vivo Nondestructive Measurement of Blood Glucose by Near-Infrared Diffuse-Reflectance Spectroscopy

Authored by: Ozaki Yukihiro , Shinzawa Hideyuki , Maruo Katsuhiko , Du Yi Ping , Kasemsumran Sumaporn

Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues

Print publication date:  December  2008
Online publication date:  December  2008

Print ISBN: 9781584889748
eBook ISBN: 9781584889755
Adobe ISBN:

10.1201/9781584889755.ch8

 Download Chapter

 

Abstract

This chapter reviews in vivo noninvasive monitoring of blood glucose by near-infrared (NIR) diffuse-reflectance (DR) spectroscopy. The NIR spectra of human forearm were measured in vivo by use of an NIR system equipped with a pair of illuminating and detecting optical fibers newly developed by our group. The optical geometry of the fibers enables the NIR measurements selectively from dermis tissue and reduces the interference noise arising from the stratum corneum. Oral glucose intake experiments were performed with six subjects (including single type I diabetes) whose NIR skin spectra were measured at the forearm. Partial least square regression (PLSR) analysis was carried out for the NIR data and calibration models were built for each subject individually. We also developed new chemometrics algorithms and data pre-treatment methods that are useful for the blood glucose assay. In the former part of this review, first the importance of in vivo noninvasive monitoring of blood glucose by NIR measurement is described, and then the NIR system we developed for the in vivo measurement is outlined. Following these the results of NIR spectral measurements and calibration models for blood glucose assay are explained. In the latter part of this review, new chemometrics algorithms for wavelength and sample selections and those for removing interference components are introduced and their applications to the in vivo NIR spectra of human skin are described.

 Cite
Search for more...
Back to top

Use of cookies on this website

We are using cookies to provide statistics that help us give you the best experience of our site. You can find out more in our Privacy Policy. By continuing to use the site you are agreeing to our use of cookies.