ABSTRACT
Laboratory animal testing provides most of our current knowledge of human physiology, microbiology, immunology, pharmacology, and pathology. From studies of genetics in fruit flies to studies of cellular processes in genetically modified mice to recent dramatic developments in genetics, translational research, and personalized medicines, biomedical
The Contribution of Laboratory Animals to Medical Progress- Past, Present, and Future. Ethics of Animal Research. An Overview of Global Legislation, Regulation and Policies. Assessment of Animal Care and Use Programs and Facilities. Education and Training. Laboratory Animal Science and Service Organizations. Laboratory Animal Allergy and Zoonoses. Laboratory Animal Facilities and Equipment for Conventional, Barrier, and Containment Housing Systems. Laboratory Animal Genetics and Genetic Quality Control. Health Status and Health Monitoring. Nutrient Requirements, Experimental Design, and Feeding Schedules in Animal Experimentation. Impact of the Biotic and Abiotic Environment on Animal Experiments. Experimental Design and Statistical Analysis. Common Nonsurgical Techniques and Procedures. Applications of Radio-Telemetry in Small Laboratory Animals. Immunization for Production of Antibodies. Laboratory Animal Analgesia, Anesthesia, and Euthanasia. Welfare Assessment and Humane Endpoints. Surgery: Basic Principles and Procedures. Microsurgical Procedures in Experimental Research. Postmortem Procedures. Alternatives: Refinement, Reduction and Replacement of Animal Uses in the Life Sciences. Generation and Analysis of Genetically Modified Mice. Physiological, Hematological, and Clinical Chemistry Parameters (including Conversion Factors).
