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Handbook of Laboratory Animal Science

Essential Principles and Practices

Edited by: Jann Hau , Steven J. Schapiro

Print publication date:  December  2010
Online publication date:  December  2010

Print ISBN: 9781420084559
eBook ISBN: 9781420084566
Adobe ISBN:

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Book description

Laboratory animal testing provides most of our current knowledge of human physiology, microbiology, immunology, pharmacology, and pathology. From studies of genetics in fruit flies to studies of cellular processes in genetically modified mice to recent dramatic developments in genetics, translational research, and personalized medicines, biomedical research involving animals remains absolutely essential for the advancement of the medical, veterinary, agricultural, and biological sciences and all rely on access to high-quality laboratory animals as models for humans.

Rooted in the principle that good science can only be performed in environments that promote good animal welfare, this third edition of the bestselling Handbook of Laboratory Animal Science, Vol. 1, Essential Principles and Practices emphasizes the importance of implementing the three R?s: replacing live animals with alternative methods, reducing the number of animals used, and refining techniques to minimize animal discomfort, and integrates these humane principles into almost every chapter.

See what's new in the Third Edition:

  • New chapters: Applications of Radio-Telemetry in Small Laboratory Animals, Generation and analysis of genetically modified mice, and Physiological, Hematological, and Clinical Chemistry Parameters
  • Additional mateiral on the international harmonization of practices and on the continued implementation of the refinement, reduction, and replacement of animal usage in laboratories
  • Sixteen page color insert

Relevant to virtually all areas of laboratory science and forming the cornerstone of laboratory animal science, each individual chapter focuses on an important subdiscipline of laboratory animal science including humane laws and guidelines; non-surgical, surgical, microsurgical, and post-mortem procedures; genetic modification; nutrition, feeding, and environmental factors; experiment design and alternative methods; and analgesia, anesthesia, and euthanasia. Each chapter can be read in series or as a stand alone text.

A truly international effort from world renowned contributors, Handbook of Laboratory Animal Science, Vol. 1, Essential Principles and Practices, Third Edition is useful as a textbook in laboratory animal science courses for postgraduate and undergraduate students, as a handbook for scientists who work with animals in their research, and for university veterinarians, regulators, and other specialists in laboratory animal science.

Table of contents

Chapter  1:  The Contribution of Laboratory Animals to Medical Progress—Past, Present, and Future Download PDF
Chapter  2:  Ethics of Animal Research Download PDF
Chapter  3:  An Overview of Global Legislation, Regulation, and Policies Download PDF
Chapter  4:  Assessment of Animal Care and Use Programs and Facilities Download PDF
Chapter  5:  Education and Training Download PDF
Chapter  6:  Laboratory Animal Science and Service Organizations Download PDF
Chapter  7:  Laboratory Animal Allergies and Zoonoses Download PDF
Chapter  8:  Laboratory Animal Facilities and Equipment for Conventional, Barrier, and Containment Housing Systems Download PDF
Chapter  9:  Laboratory Animal Genetics and Genetic Quality Control Download PDF
Chapter  10:  Health Status and Health Monitoring Download PDF
Chapter  11:  Nutrient Requirements, Experimental Design, and Feeding schedules in Animal Experimentation Download PDF
Chapter  12:  Impact of the Biotic and Abiotic Environment on Animal Experiments Download PDF
Chapter  13:  Experimental Design and Statistical Analysis Download PDF
Chapter  14:  Common Nonsurgical Techniques and Procedures Download PDF
Chapter  15:  Applications of Radiotelemetry in Small Laboratory Animals Download PDF
Chapter  16:  Immunization for Production of Antibodies Download PDF
Chapter  17:  Laboratory Animal Analgesia, Anesthesia, and Euthanasia Download PDF
Chapter  18:  Welfare Assessment and Humane End Points Download PDF
Chapter  19:  Surgery Download PDF
Chapter  20:  Microsurgical Procedures in Experimental Research Download PDF
Chapter  21:  Postmortem Procedures Download PDF
Chapter  22:  Alternatives Download PDF
Chapter  23:  Generation and Analysis of Genetically Modified Mice Download PDF
Chapter  24:  Physiological, Hematological, and Clinical Chemistry Parameters, Including Conversion Factors Download PDF
prelims Download PDF
Index Download PDF
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