MCMC in the Analysis of Genetic Data on Related Individuals

Authored by: Elizabeth Thompson

Handbook of Markov Chain Monte Carlo

Print publication date:  May  2011
Online publication date:  May  2011

Print ISBN: 9781420079418
eBook ISBN: 9781420079425
Adobe ISBN:

10.1201/b10905-16

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Abstract

This chapter provides an overview of the use of Markov chain Monte Carlo (MCMC) methods in the analysis of data observed for multiple genetic loci on members of extended pedigrees in which there are many missing data. Rather than on the details of the MCMC sampling methods, our focus is first on the complex structure of these data that necessitates MCMC methods, and second on the use of Monte Carlo realizations of latent variables in statistical inference in this area.

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