Vitamin K

Authored by: Xueyan Fu , Sarah L. Booth

Handbook of Analysis of Active Compounds in Functional Foods

Print publication date:  January  2012
Online publication date:  January  2012

Print ISBN: 9781439815885
eBook ISBN: 9781439815908
Adobe ISBN:

10.1201/b11653-9

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Abstract

Vitamin K, a fat-soluble vitamin, is an enzyme cofactor for posttranslational modification of a select group of proteins. In the presence of vitamin K, specific glutamate residues are converted into ?-carboxyglutamic acid (Gla) residues by a vitamin K-dependent (VKD) carboxylase. The VKD coagulation proteins, factors II, VII, IX, and X, and proteins C, S, and Z, are synthesized in the liver (Berkner, 2005). The extra-hepatic VKD proteins include osteocalcin (Hauschka et al., 1975; Price et al., 1976), Matrix Gla-protein (Price et al., 1983), Gla-rich protein (Viegas et al., 2008), periosin (Coutu et al., 2008), Tgfbi (Ahmed et al., 2007; Zhang et al., 2009), and Gas-6 (Shearer, 2000; Berkner and Runge, 2004).

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