Population Stratification with Mixed Membership Models

Authored by: Edoardo M. Airoldi , David M. Blei , Elena A. Erosheva , Stephen E. Fienberg , Suyash Shringarpure , Eric P. Xing

Handbook of Mixed Membership Models and Their Applications

Print publication date:  November  2014
Online publication date:  November  2014

Print ISBN: 9781466504080
eBook ISBN: 9781466504097
Adobe ISBN:

10.1201/b17520-25

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Abstract

Population stratification (or population structure) is the presence of genotypic differences among different groups of individuals. Genotype-based clustering of individuals is an important way of summarizing the genetic similarities and differences between groups of individuals. It enables us to formulate and test hypotheses regarding evolutionary history of populations. Identifying population stratification is also important in genetic association studies and other population genetic analyses.

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