Two-pore domain potassium channels

Authored by: D. Plant Leigh , A.N. Goldstein Steve

Handbook of Ion Channels

Print publication date:  February  2015
Online publication date:  February  2015

Print ISBN: 9781466551404
eBook ISBN: 9781466551428
Adobe ISBN:

10.1201/b18027-23

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Abstract

The ability of the central nervous system (CNS) to receive, integrate, and process information is dependent on the operation of a finely tuned orchestra of receptors and ion channels that reside at the surface of excitable cells. Among the ensemble at the neuronal plasma membrane are many types of K+ channels that act together to control some of the most fundamental determinants of excitable behavior, in particular, the frequency and duration of action potentials and the resting membrane potential (VM). It is valuable therefore to understand the structural basis for K+ channel function, the role of K+ channels in physiology, and the factors that regulate K+ channel activity in health and disease. In this chapter, we consider the most recently discovered family of mammalian K+ channels, the predominant contributors to background (leak) K+ currents, the two-pore domain K+ (K2P) channels.

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