5-HT receptors

Authored by: C.R. Lummis Sarah

Handbook of Ion Channels

Print publication date:  February  2015
Online publication date:  February  2015

Print ISBN: 9781466551404
eBook ISBN: 9781466551428
Adobe ISBN:

10.1201/b18027-26

 Download Chapter

 

Abstract

The 5-HT3 receptor is a Cys-loop ligand-gated ion channel and is structurally and functionally distinct from the other six classes of 5-HT receptors whose actions are mediated via G-proteins. 5-HT3 receptors are pentamers, and five classes of subunit have been identified. These are widely distributed, both in the nervous system and in other tissues. 5-HT3 receptor activation opens a cation-selective ion channel, and receptor function can be modulated by a wide range of compounds including anesthetics, opioids, and alcohols. 5-HT3 receptors play a major role in the vomiting reflex; regulate gut motility, secretion, and peristalsis in the enteric nervous system; and are involved in information transfer in the gastrointestinal (GI) tract. Disturbances within the 5-HT3 receptor system may contribute to the etiopathogenesis of a range of neurological, GI, and immunological disorders.

 Cite
Search for more...
Back to top

Use of cookies on this website

We are using cookies to provide statistics that help us give you the best experience of our site. You can find out more in our Privacy Policy. By continuing to use the site you are agreeing to our use of cookies.