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Ca-activated chloride channels
- Introduction
- TMEM16A Encodes the Classic CaCC
- Biophysical Properties of TMEM16A
- Topology
- Calcium and Voltage Sensing
- Stoichiometry
- Molecular Determinants of Ionic Selectivity
- Pharmacology
- Posttranslational Modifications and Channel Function
- Functional Implications of TMEM16A
- Development and Cancer
- Sensory Transduction
- Smooth Muscle Tone
- Exocrine Secretion and Epithelial Maintenance
- TMEM16B
- Other Mammalian TMEM16 Family Members
- References
Abstract
Eukaryotes have evolved sophisticated and ubiquitous calcium signaling pathways, and correspondingly, calcium-activated chloride channels (CaCCs) are implicated in physiological processes in a multitude of organisms and tissue types.
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