ABSTRACT

Grayanotoxins (GTXs) are a group of toxic compounds classified as polyhydroxylated cyclic diterpenes. GTXs, also known as andromedotoxin, acetylandromedol, and rhodotoxin, are found in the leaves, flowers, twigs, and nectar of the genera Rhododendron, Pieris, Agarista, and Kalmia of the botanical family Ericaceæ. Of these, the genus Rhododendron with more than one thousand species 1 is one of the largest genera of vascular plants native to the northern hemisphere. 2 Grayanotoxins may also be found in a number of products originating from these plants, for example, honey, tea, and extracts used in folk medicine.