ABSTRACT
402 403 404
Compound
M.W.
Log P a
Water Solubility(g/L) b
Acetamide
59.07
−1.26
2.25 × 103
Acetic acid
60.05
−0.17
10 × 103
Acetic anhydride
102.09
−0.58
1.2 × 102
Acetoacetic acid
102.1
−0.98
1 × 103
Acetoin
88.11
−0.36
1 × 103
Acetone
58.08
−0.24
1 × 103
Acetophenone
120.15
1.58
6.13
N-Acetylcysteinamide
162.21
−0.29
5.8
N-Acetylcysteine
−0.64
N-Acetylmethionine
−0.49
Acetylsalicylic acid
180.16
1.19
4.6
Acridine
179.22
3.40
0.03
Acrolein
56.06
−0.01
2.13 × 102
Acrylamide
71.08
−0.67
6.4 × 102
Adenine
135.13
−0.09
1.0
Adenosine
267.25
−1.05
8.2
Alanine
89.09
−2.96
1.7 × 102
Aldosterone
1.08
9-Aminoacridine
194.23
2.74
0.02
4-Aminobenzoic acid (p-aminobenzoic acid; PABA)
151.17
1.03
9.89
4-Aminobutyric acid (γ-aminobutyric acid; GABA)
103.12
−3.17
1.3 × 103
6-Aminohexanoic acid (ε-aminocaproic acid)
131.18
−2.95
5.05 × 102
Aminopyrine [4-(dimethylamino)-1,5-dimethyl-2-phenylpyrazol-3-one]
231.4
0.5
23.8
Ammonium picrate
246.14
−1.40
1.6 × 102
Aniline
0.9
Anisole
2.11
ANS (1-amino-2-naphthalenesulfonic acid)
222.25
−0.97
2.23
Anthracene
4.45
Arabinose
150.13
−3.02
103
Arginine
174.20
−4.20
1.82 × 102
Ascorbic acid
176.13
−1.64
1 × 103
Asparagine
132.12
−3.82
29.4
Aspartic acid
133.10
−3.89
5.0
Aspirin (Acetylsalicylicacid; 2-acetoxybenzoic acid)
180.16
1.23
7
Barbital (5,5-diethylbarbituric acid)
184.20
0.65
7
Barbituric acid
128.1
−1.47
Benzamide
121.14
0.64
13.5
Benzamidine
120.16
0.65
27.9
Benzene
78.11
2.13
0.002
Benzoic acid
122.12
1.87
3.4
Betaine
117.15
−4.93
6.11 × 102
Biuret (imidodicarbonicacid)
103.08
1.5
Bromoacetic acid
138.95
0.41
93
2-Bromopropionic acid
152.98
0.92
29.9
Bufexamac[2-(4-butoxyphenyl)-N-hydroxyacetamide]
223.3
0.77
1.1
2,3-Butanediol
90.12
−0.36
7.6 × 102
2,3-Butanedione
86.09
−1.34
2 × 102
Butyl urea
116.16
0.41
46.3
3-Butyl hydroxy urea
132.16
0.32
23.5
Cacodylic acid
138.00
0.36
2 × 103
Carbon tetrachloride
153.82
2.83
0.8
Cholesterol
386.67
8.74
0.9
Chloroacetamide
93.51
−0.53
90
Chloroacetic anhydride
170.98
−0.07
68
Chloroacetyl chloride
112.94
−0.22
1.6 × 102
Chloroform
119.38
1.97
8
6-Chloroindole
151.60
3.25
0.1
p-Chloromercuribenzoic acid
357.16
1.48
0.3
Chlorosuccinic acid
152.54
−0.57
1.8 × 102
Cholic acid
405.58
2.02
0.2
Citric acid
192.13
−1.72
5.92 × 102
Congo red
696.68
2.63
1.2 × 102
Corticosterone
1.94
Cortisone
2.88
Creatine
132.14
−3.72
13.3
Creatinine
113.12
−1.76
80
Crotonaldehyde (2-butenal)
70.09
0.60
1.8 × 102
Cyanoacetic acid
85.06
−0.76
7.7 × 102
Cyanogen
52.04
0.07
1.2 × 102
Cyanuric acid
129.08
0.61
2
Cyclohexanone
0.81
Cysteine
121.16
−2.49
1.1 × 102
Cystine
240.30
−5.08
0.2
Cytidine
243.22
−2.51
1.8 × 102
Cytosine
111.10
−1.73
8
Deoxycholic acid
392.58
3.50
0.04
Deoxycorticosterone
2.88
Dexamethasone
2.01
Diazomethane
42.04
2.00
2
Dichloromethane
1.2
Diclofenac acid (2-[2-(2,6-dichloroanalino)phenyl]acetic acid)
295.14
4.5
0.002
Diclofenac acid (2-[2-(2,6-dichloroanalino)phenyl]acetate, sodium salt)
318.13
0.7
Dicumarol
336.30
2.07
0.1
Diethyl ether (ethyl ether; ether)
74.1
0.9
Diethylsuberate
230.31
3.35
0.7
Diethylsulfone
122.19
−0.59
1.4 × 102
N,N-Diethyl urea
116.2
0.1
4
Dihydroxyacetone
88.11
−0.49
16.2
Diisopropyl fluorophosphate (DFP)
184.15
1.17
15.4
Diketene
84.08
−0.39
5.3 × 102
Dimethylformamide
−1.04
Dimethylguanidine
87.13
−0.95
1.6
Dimethylsulfoxide
78.13
−1.35
1 × 103
Dimethylphthalate
1.56
1,4-Dinitrobenzene
1.47
2,4-Dinitrophenol
1.55
EDTA
292.25
−3.86
1
EDTA, tetrasodium salt
360.17
−13.17
5.0 × 102
Ethanol (ethyl alcohol)
46.07
−0.31
1 × 103
N-Hydroxy-1-ethylurea
104.11
−0.10
7
N-Ethylnicotinamide
150.18
0.31
41.2
Estradiol
2.69
N-Ethylthiourea
104.17
−0.21
24
Ethylurea
88.11
−0.74
26.4
Ethylene glycol
2.07
−1.36
1 × 103
Ethylene oxide
44.05
−0.30
1 × 103
Flufenamic acid (2[3-(trifluoromethyl)anilino]benzoic acid)
281.23
5.25
0.009
Fluorescein
333.32
3.35
0.05
Fluoroacetone
76.07
−0.39
286
Flurbiprofen [2-(3-fluoro-4-phenylphenyl)propionic acid]
244.26
4.16
0.008
Folic acid
441.41
−2.00
0.002
Formaldehyde
30.03
0.35
400
Formic acid
48.03
−0.54
1 × 103
Galactose
180.16
−2.43
683
Glucose
180.16
−3.00
≥1 × 103
Glutamic acid
147.10
−3.69
8.6
Glutamine
146.15
−3.64
41
Glycerol
92.10
−1.76
1 × 103
Glycine
75.10
−3.21
2.5 × 102
Glyoxal
58.04
−1.66
1 × 103
Glyoxylic acid
74.04
−1.40
1 × 103
Guanidine
59.07
−1.63
1.8
Guanine
151.13
−0.91
2.1
Guanosine
283.25
−1.90
0.7
Hexanal
100.16
1.78
6
Hydroxyproline
131.13
−3.17
395
Hydroxyurea (N-hydroxyurea)
76.06
−1.80
200
N-Hydroxy-1-ethylurea
104.11
−0.10
7
Indole
117.15
2.14
4
Inositol
180.16
−2.08
143
Iodoacetamide
184.96
−0.19
76
Isoleucine
131.18
−1.70
34
Isopropanol
60.10
0.05
1 × 103
Ketoprofen [2-(3-benzoylphenyl)propanoic acid]
254.28
3.12
0.02
Lactic acid
90.08
−0.72
1 × 103
Lactose
342.30
−5.43
195
Leucine
131.18
−1.52
22
Linoleic acid
280.45
7.05
0.00004
Lysine
146.19
−3.05
1 × 103
Maleic anhydride
98.06
1.62
5
Maltose
342.30
−5.43
780
Mannitol
182.17
−3.10
216
Mefenamic acid (2-[2(2,3-dimethylphenyl)amino]benzoic acid)
241.29
5.12
0.020
Mercaptoacetic acid
92.12
0.09
1 × 103
2-Mercaptobenzoic acid
154.19
2.39
0.7
Methane
16.04
1.09
0.002
Methanol
32.04
−0.77
1 × 103
Methionine
149.21
−1.87
57
Methotrexate
454.45
−1.85
2.6
Methylene blue
319.86
5.85
44
N-Methyl glycine
89.09
−2.78
300
5-Methylindole
131.18
2.68
0.5
Methyl isocyanate
57.05
0.79
29
Methylmalonic acid
118.09
−0.83
680
Methyl methacrylate
86.09
0.80
49
Methylmethane sulfonate
110.13
−0.66
1 × 103
Methyl thiocyanate
73.12
0.73
32
N-Methyl thiourea
119.21
−0.69
240
Methyl urea
74.08
−1.40
100
Naphthalene
128.17
3.29
0.031
Naproxen
230.26
3.18
0.016
Nicotinic acid
123.11
0.36
18
Ornithine
132.16
−4.22
1 × 103
Orotic acid
156.10
−0.83
2
Oxalic acid
90.06
−2.22
Oxindole
133.15
1.16
9
Palmitic acid
256.43
7.17
0.0008
Paraldehyde
132.16
0.67
112
Pentobarbital
226.28
2.10
0.7
Phenol
94.11
1.46
83
Phenylalanine
165.19
−1.52
22
Phosgene
98.02
−0.71
475
Proline
115.13
−2.54
131
Prostaglandin E2
352.48
2.82
0.006
Propylamine
59.11
0.48
1 × 103
Propylene oxide
58.08
0.03
595
Pyridine
79.10
0.65
1 × 103
Pyridoxal
203.63
−3.32
500
Pyridoxal-5-phosphate
247.15
0.37
20
Pyridoxine
169.18
−0.77
282
Pyruvic acid
88.06
−1.24
1 × 103
Ribose
150.13
−2.32
Salicylic acid
138.12
2.26
2.24
Sarin
140.10
0.72
1 × 103
Serine
105.09
−3.07
425
Sorbic acid
112.13
1.33
2
Sorbitol
182.17
−2.20
3 × 103
Stearic acid
284.49
8.23
0.03
Succinic anhydride
100.07
0.81
24
Succinimide
99.09
−0.85
196
Sucrose
342.30
−3.70
2.12 × 103
Testosterone
288.43
3.32
0.03
Tetrahydrofuran
72.11
0.46
1 × 103
Threonine
119.12
−2.94
97
Toluene
92.14
2.73
0.5
2,4,6-Trinitrobenzene
257.12
0.23
21
Tryptophan
204.23
−1.06
12
Urea
60.06
−2.11
545
Valine
117.15
−2.26
60
Source: Adapted from Howard, P.H., and Meylan, W.M. ed. Handbook of Physical Properties of Organic Chemicals, CRC Press, Boca Raton, FL, 1997 and other numerous other sources including PubChem.Log P = log concentration in oil/concentration in water, a partition coefficient, K = oil/water; see above Howard and Meylan and following for discussion of log P.
Solubility values taken from various literature sources and in some cases are approximations. Data is assumed at 20°C–25°C. Some values are estimates. A value of 1 × 103 g/L means approximately 1 gm solute in 1 mL H2O or, in the case of a liquid, the liquid is miscible with H2O.
