ABSTRACT

The preceding Chapters 15 and 16 focused on the overall genetic influence on cardiorespiratory fitness and mitochondrial function during physical performance, respectively. This chapter will focus specifically on the influence of the angiotensin-converting enzyme gene (ACE) on human physical performance that was first studied by Montgomery and colleagues in 1998 (39). ACE has now become the most investigated gene in relation to human physical performance (57). Our search in PubMed located 316 citations that involved ACE and all types of physical performance. The number of yearly citations in PubMed from 1998 to 2017 involving ACE and all types of physical performance is displayed in Figure 17.1. Please note the search terms for this search differed slightly from the search conducted for this chapter on ACE and endurance performance, as we wished to emphasize the extent to which ACE is cited in the exercise performance literature.