Drug Delivery: PLGA-PEG-Based Bioerodable Nanoparticles

Authored by: Arindam Maity , Kazi Asraf Ali , Debanjana Chakraborty , Sougata Jana

Encyclopedia of Polymer Applications

Print publication date:  January  2019
Online publication date:  December  2018

Print ISBN: 9781498729932
eBook ISBN: 9781351019422
Adobe ISBN:

10.4324/9781351019422-140000088

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Abstract

In this entry, we begin with a detailed discussion of poly(lactic acid-co-glycolic acid)–polyethylene glycol (PLGA–PEG) di-, tri-, and multi-block copolymers which were chosen as a typical model of copolymer for the construction of different nano-sized drug delivery systems. We also discuss its properties, characteristics, and different nanoparticles (NPs) formulation methods. Here, we discuss the different PLGA–PEG copolymers bound or coated with drugs, proteins, aptamer, etc. and their different aspects of application in drug delivery systems. In addition, the drug-loading forms of PLGA–PEG NPs were discussed with different aspects of pharmacological and other biological applications. This entry reviews the detailed information regarding the development of PLGA–PEG drug delivery form, its characteristics, and its applications.

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