Abstract

In this entry, we begin with a detailed discussion of poly(lactic acid-co-glycolic acid)–polyethylene glycol (PLGA–PEG) di-, tri-, and multi-block copolymers which were chosen as a typical model of copolymer for the construction of different nano-sized drug delivery systems. We also discuss its properties, characteristics, and different nanoparticles (NPs) formulation methods. Here, we discuss the different PLGA–PEG copolymers bound or coated with drugs, proteins, aptamer, etc. and their different aspects of application in drug delivery systems. In addition, the drug-loading forms of PLGA–PEG NPs were discussed with different aspects of pharmacological and other biological applications. This entry reviews the detailed information regarding the development of PLGA–PEG drug delivery form, its characteristics, and its applications.